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Mefenamic acid


Mefenamic acid (Acidum mephenamicum).
N-(2, 3-dimethylphenyl)-anthranilic acid.
Synonyms: Acidum mefenamicum, Coslan, Lysalgo, Mefenamic acid, Parkemed, Ponstan, Ponstel, Ponstyl, Pontal, Tanston etc.
Crystalline powder is grayish-white color. Practically insoluble in water, slightly soluble in alcohol.
Mefenamic acid is a derivative of anthranilic acid, which has elements of the structural similarities to salicylic acid and its derivatives, used as anti-inflammatory drugs. She has analgeziruyuschey, antipyretic and anti-inflammatory activity, both anti-inflammatory activity is superior to salicylates. By analgeziruyuschey activity mefenamic acid equivalent phenylbutazone and salicylates superior, and for antipyretic effect is equal to these drugs.
On mechanism of mefenamic acid is similar to other nonsteroidal anti-inflammatory substances. By the ability to inhibit the biosynthesis of prostaglandins occupies an intermediate position between phenylbutazone and indomethacin.
Mefenamic acid is used in rheumatism and nonspecific infectious arthritis, arthralgia and muscle pain, neuralgia, and headache, toothache, etc. and as an antipyretic in various febrile conditions.
Assign inside (after eating) for adults at 0, 5 g of 3 - 4 times a day. If necessary, and good endurance, increase the daily dose to a maximum of 3 grams, but after reaching the therapeutic effect of the dose was lowered to 1 g per day. Children aged 5 to 10 years are designated by 0, 25 g of 3 - 4 times a day, over 10 years - 0, 3 g of 3 - 4 times a day.
Duration of treatment depends on the specifics of the case and tolerability of the drug, usually a course of treatment lasts 20 - 45 days (if necessary up to 2 months).
The drug is generally well tolerated (sometimes prescribed for poor tolerance of salicylates), but it can cause nausea, abdominal pain, diarrhea. To prevent these phenomena take medication after meals. It is recommended to wash down pills with milk. In some cases, possible allergic effects (itching, rash).
Mefenamic acid is contraindicated in peptic ulcer of the stomach and duodenum and inflammatory diseases of the gastrointestinal tract.
Be careful when appointing the drug to patients with diseases of the blood-forming organs and kidneys.
Product: pills grayish-white at 0, 25, 0, 35 and 0, 5 grams in a package of 50 pieces.
Storage: List B. In dry place, protected from light.
Overseas (India) issued a combined medication - pills <Lanagesik>> (Lanagesic), containing 0, 25 g of mefenamic acid and 0, 5 g of paracetamol.
 

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